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Prather, Paul

One or more keywords matched the following items that are connected to Prather, Paul

Item Type	Name
Academic Article	The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors.
Academic Article	The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset.
Academic Article	A major glucuronidated metabolite of JWH-018 is a neutral antagonist at CB1 receptors.
Academic Article	AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies.
Academic Article	The dietary polyphenols trans-resveratrol and curcumin selectively bind human CB1 cannabinoid receptors with nanomolar affinities and function as antagonists/inverse agonists.
Academic Article	Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs.
Academic Article	Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse.
Academic Article	Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids.
Academic Article	Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors.
Academic Article	Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors.
Academic Article	Forensic investigation of K2, Spice, and "bath salt" commercial preparations: a three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds.
Academic Article	Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors.
Academic Article	Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.
Academic Article	Effects of the ?-agonist, isoprenaline, on the down-regulation, functional responsiveness and trafficking of ?2-adrenergic receptors with N-terminal polymorphisms.
Academic Article	CB1 and CB2 receptors are novel molecular targets for Tamoxifen and 4OH-Tamoxifen.
Academic Article	Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?
Academic Article	Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine.
Academic Article	Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
Academic Article	Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors.
Concept	Humans
Academic Article	Some new insights into the effects of opioids in phasic and tonic nociceptive tests.
Academic Article	Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to ?(9)-THC: mechanism underlying greater toxicity?
Academic Article	The K2/Spice phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products.
Academic Article	Endogenous Control of Long Term Seizure Susceptibility: Behavioral and Pharmacological Influence
Academic Article	Gambogic acid binds to human CB2 receptors and exhibits potential partial agonist activity
Academic Article	The omega and omega-1 monohydroxyl metabolites of the abused K2/Spice synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as agonists at human cannabinoid 2 receptors (hCB2s)
Academic Article	Biotransformation of abused synthetic cannabinoids in K2/Spice by human hepatic and extrahepatic UDP-glucuronosyltransferase (UGTs)
Academic Article	Noladin ether acts as a full agonist at human CB2 cannabinoid receptors stably expressed in CHO cells
Academic Article	Quantitative measuerment of JWH-018 and JWH-073 metabolites excerted in human urine
Academic Article	In Methods for Discovery and Characterization of G-Protien-coupled Receptors
Academic Article	Gambogic acid and its analogues are novel substrates for human UDP-glucuonosyltransferase and bind cannabinoid receptors CB1 and CB2
Academic Article	Mu and delta receptor desensitization in undifferentiated human neuroblastoma SH-SY-5Y cells
Academic Article	Natural resveratrol analogues arachidin-1, arachidin-4 and hydroxylated metabolites binding human and mice cannabinoid receptors CB1 and CB2,
Academic Article	Ondansetron-induced reversal of anxiogenic behaviors upon withdrawal from ethanol: Assessment by behavioral alterations in the elevated plus-maze
Academic Article	Human UDP-glucuronosyltransferases (UGTs) are involved in the metabolism of transArachidins and Piceatannol
Academic Article	Characterization of the intrinsic activity for a novel class of cannabinoid receptor ligands: Indole quinuclidine analogs.
Academic Article	Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development.
Academic Article	Synthetic Pot: Not Your Grandfather's Marijuana.
Academic Article	Preface to DMR special edition 'Cannabinoid receptors and ligands: therapeutic drug development and abuse potential'.
Academic Article	Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants.
Grant	Systems Pharmacology and Toxicology Training Program
Grant	Synthetic Cannabinoid Toxicity: Role of Biotransformation
Academic Article	Enzymatic analysis of glucuronidation of synthetic cannabinoid 1-naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate (FDU-PB-22).
Grant	Use of precision deuteration to determine the contribution of norbuprenorphine to buprenorphine-associated neonatal abstinence syndrome
Academic Article	Identifying cytochrome P450s involved in oxidative metabolism of synthetic cannabinoid N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide (STS-135).
Academic Article	Metabolism, CB1 cannabinoid receptor binding and in vivo activity of synthetic cannabinoid 5F-AKB48: Implications for toxicity.
Academic Article	7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands.
Academic Article	Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics.
Academic Article	Synthesis, Molecular Pharmacology, and Structure-Activity Relationships of 3-(Indanoyl)indoles as Selective Cannabinoid Type 2 Receptor Antagonists.
Academic Article	Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71 and A-673 cells as potential targets for anti-cancer drug development.
Academic Article	Non-Canonical Cannabinoid Receptors with Distinct Binding and Signaling Properties in Prostate and Other Cancer Cell Types Mediate Cell Death.
Grant	Training in Systems Pharmacology and Toxicology (T-SPaT)
Academic Article	Similar 5F-APINACA Metabolism between CD-1 Mouse and Human Liver Microsomes Involves Different P450 Cytochromes.
Grant	Training in Systems Pharmacology and Toxicology (T-SPaT)
Grant	Training in Systems Pharmacology and Toxicology (T-SPaT)

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